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Monitor Carefully (one)pentobarbital will minimize the level or influence of hydrocodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Warning when discontinuing CYP3A4 inducers which might be coadministered with hydrocodone; plasma concentrations of hydrocodone could improve and may result in probably dea

Barbiturates might be routine forming. Tolerance, psychological and Actual physical dependence might arise with ongoing use. (See “Drug Abuse And Dependence” and “Pharmacokinetics” sections.) Individuals that have psychological dependence on barbiturates might improve the dosage or reduce the dosage interval devoid of consulting a health pr